Two-dimensional (2D) materials have recently received much attraction in the scientific communities because of their unique properties and extensive applications. A prominent aspect of 2D materials is their applications in quantum technologies where single photons are essential. Observation and investigation of single photons in 2D materials such as h-BN, transition metal dichalcogenides, WO3, and GaSe, has raised a great interest toward this class of materials in the field of single-photon emitters (SPEs). SPEs in 2D materials are applicable in many quantum technologies ranging from quantum nanophotonics to quantum sensing and quantum information processing. In such materials, the 2D nature of the host considerably improves the photon-extraction efficiency, provides more control over the defect implantation techniques, eases coupling to the waveguides, and provides compatibility with other 2D materials. These advantages have inspired us to search and find 2D materials in which all the desired properties of an efficient single-photon source are met.